| 1. | However , models do not address resistance mechanisms that contribute to acquired drug resistance
但是，这些模型不能解释肿瘤获得性耐药的机制。 |
| 2. | Our review focused on microenvironment and its role in mediating acquired drug resistance
本文就肿瘤微环境及其在介导获得性耐药和凋亡抵抗中的作用作综述。 |
| 3. | Therefore , to improve the efficacy of cancer chemotherapy , seeking and identifying the mechanisms of acquired drug resistance become a hotspot in current researches
因此，为了提高肿瘤化疗的效果，寻找和辨识肿瘤获得性耐药机制已成为当今研究的热点。 |
| 4. | Many researches have suggested that tumor microenvironment plays an important role in mediating acquired drug resistance and confers resistance to physiologic mediators of cell death
目前，大量研究认为肿瘤微环境在介导肿瘤获得性耐药和抵抗细胞死亡的生理性调节中发挥了重要作用。 |
| 5. | The specific niches within it may provide a sanctuary for subpopulations tumor cells that affords a survival advantage following initial drug exposure and may promote acquired drug resistance
肿瘤微环境中特殊的生态位可能为肿瘤细胞亚群提供了一个“避难所” ，即在最初暴露于化疗药物之后提供了一种生存优势，它促进了肿瘤获得性耐药的发生。 |
